Chromatography Standards
Medchemexpress LLC Amoxicillin (trihydrate) mixture with potassium clavulanate (4:1) | 25 MG
Amoxicillin (trihydrate) mixture with potassium clavulanate (4:1) is an antibiotic characterized by good oral absorption and broad-spectrum antimicrobial activity. It functions by inhibiting the biosynthesis of polypeptides in the cell wall, thereby hindering cell growth.
- Good oral absorption
- Broad-spectrum antimicrobial activity
- Inhibits biosynthesis of polypeptides in the cell wall
- Inhibits cell growth
- For research use only
Medchemexpress LLC Neostigmine methyl sulfate | 51-60-5 | 98.9% | 100 MG
Neostigmine methyl sulfate (Standard) serves as an analytical standard, designed for research and analytical applications. This reference standard assay is widely utilized in qualitative, quantitative, and methodological research experiments, including techniques such as HPLC, GC, and MS.
- Intended for research and analytical applications.
- Functions as a reference standard supplied assay.
- Used in qualitative, quantitative, and methodological research.
- Suitable for techniques including HPLC, GC, and MS.
Medchemexpress LLC Promazine hydrochloride | 53-60-1 | 99.9% | 1 ML
Promazine hydrochloride is an antipsychotic and a dopamine receptor D2 antagonist that inhibits dopaminergic neurotransmission. It is supplied as a solid, white to off-white powder.
- Antipsychotic and dopamine receptor D2 antagonist
- Inhibits dopaminergic neurotransmission
- Shows KDs of 25, 190, and 8400 nM at human norepinephrine, serotonin, and dopamine transporters
- Molecular weight: 320.88
- Chemical formula: C17H21ClN2S
- Soluble in water and DMSO at 100 mg/mL
Apexbio Technology LLC Fostamatinib (R788) 901119-35-5 100mg
Fostamatinib (R788 CAS 901119-35-5) is an orally available small-molecule inhibitor targeting spleen tyrosine kinase (Syk) with an IC50 of approximately 41 nM As a prodrug fostamatinib is rapidly converted to its active metabolite R406 an ATP-competitive inhibitor of Syk (Ki 30 nM) R406 additionally inhibits related kinases such as Flt3 Lyn (IC50 63 nM) and Lck (IC50 37 nM) thereby modulating BCR- and Fc receptor-mediated signaling pathways Preclinical studies demonstrate activity of fostamatinib in various autoimmune and inflammatory models including SLE-related nephritis and dermatitis in MRL/lpr mice highlighting its utility as a research tool in autoimmune disease investigation
Apexbio Technology LLC Eltrombopag Olamine 496775-62-3 50mg
Eltrombopag Olamine is an orally bioavailable thrombopoietin receptor (c-mpl) agonist that directly stimulates platelet production through activation of the JAK2/STAT signaling pathway In cellular assays using murine BAF3 cells expressing human thrombopoietin receptor (hTpoR) eltrombopag induced STAT-dependent signaling responses with an EC50 value of approximately 0 27 M This compound promotes differentiation of human CD34 progenitor cells into megakaryocytes capable of platelet production Eltrombopag is commonly applied in hematological research particularly in studies involving thrombocytopenia and thrombopoiesis-related mechanisms
Medchemexpress LLC Larotrectinib | 1223403-58-4 | 99.9% | 10 MG
Larotrectinib is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors. It demonstrates low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C) and exhibits 1,000-fold or greater selectivity relative to other kinases. This product is for research use only.
- Targets TrkA, TrkB, and TrkC
- Exhibits antiproliferative activity against various cell lines
- Demonstrates dose-dependent inhibition of cell proliferation
- Has low brain penetration in animal studies
- Well tolerated in GLP toxicology studies
- Reduces tyrosine phosphorylation of TRKA and downstream signal transduction in tumors
- Shows dose-dependent tumor inhibition in athymic nude mice
- Reduces leukemic infiltration in bone marrow and spleen in mice
Medchemexpress LLC Diclofenac epolamine | 119623-66-4 | 100.0% | 411.32 | 50 MG
Diclofenac epolamine is a non-steroidal anti-inflammatory drug (NSAID) used for relieving arthritis pain, acute pain, osteoarthritis, and actinic keratosis. It demonstrates good skin absorption characteristics without local adverse reactions or allergies.
- Relieves arthritis pain, acute pain, osteoarthritis, and actinic keratosis.
- Demonstrates good skin absorption characteristics.
- Does not cause local adverse reactions or allergies.
- Effective in treating inflammatory conditions.
- Increases partitioning into the skin.
- Enhances and sustains drug transport through the skin.
Medchemexpress LLC Naphazoline nitrate | 5144-52-5 | MFCD00014316 | 99.1% | 273.29 | 50 MG
Naphazoline nitrate is an α-adrenergic receptor agonist that reduces vascular hyperpermeability and promotes vasoconstriction. It is also known to reduce levels of inflammatory factors, cytokines, IgE, GMCSF, and NGF, making it suitable for non-bacterial conjunctivitis research.
- α-adrenergic receptor agonist
- Reduces vascular hyperpermeability
- Promotes vasoconstriction
- Reduces levels of inflammatory factors (TNF-α, IL-1β, IL-6)
- Reduces levels of cytokines (IFN-γ, IL-4)
- Reduces IgE, GMCSF, and NGF
- Can be used for non-bacterial conjunctivitis research
Medchemexpress LLC Naphazoline nitrate | 5144-52-5 | 99.1% | 273.29 | 100 MG
Naphazoline nitrate is an α-adrenergic receptor agonist that reduces vascular hyperpermeability and promotes vasoconstriction. It also reduces levels of inflammatory factors and can be used for non-bacterial conjunctivitis research.
- Targets α-adrenergic receptors
- Helps manage vascular issues
- Decreases levels of TNF-α, IL-1β, IL-6, IFN-γ, IL-4, IgE, GMCSF, and NGF
- Applicable for non-bacterial conjunctivitis research
- Solid, white to off-white appearance
- Solubility: 100 mg/mL in DMSO
Medchemexpress LLC Gemcitabine monophosphate disodium | 1638288-31-9 | 387.14 | 10 MM * 1 ML
Gemcitabine monophosphate (Gemcitabine 5′-phosphate) is one of the active intermediates of Gemcitabine. It has a synergistic anti-cancer effect and can be delivered by formulating it into nanoparticles.
- Active intermediate of Gemcitabine.
- Synergistic anti-cancer effect.
- Can be delivered via nanoparticles.
- In vivo studies show it induces tumor cell apoptosis (30-40%), reduces tumor cell proliferation by 8 times, significantly reduces tumor microvessel density (MVD), and inhibits tumor mitosis in subcutaneous and orthotopic xenograft mouse models of non-small cell lung cancer.
Medchemexpress LLC Naphazoline | 835-31-4 | MFCD00066737 | 99.7% | 210.27 | 25 MG
Naphazoline is a potent α-adrenergic receptor agonist that reduces vascular hyperpermeability and promotes vasoconstriction. It also reduces the levels of inflammatory factors (TNF-α, IL-1β, and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. It can be used for non-bacterial conjunctivitis research.
- Reduces vascular hyperpermeability
- Promotes vasoconstriction
- Reduces inflammatory factors and cytokines
- Used for non-bacterial conjunctivitis research
Medchemexpress LLC Isradipine | 75695-93-1 | 5 MG
Isradipine is an orally active, blood-brain barrier permeable L-type calcium channel blocker. It functions as a potent peripheral vasodilator and is a dihydropyridine calcium antagonist with selective effects on the heart and peripheral circulation. Isradipine is considered a potentially viable neuroprotective agent for Parkinson's disease.
- Orally active
- Blood-brain barrier permeable
- L-type calcium channel blocker
- Potent peripheral vasodilator
- Dihydropyridine calcium antagonist with selective effects on the heart and peripheral circulation
- Potentially viable neuroprotective agent for Parkinson's disease
Medchemexpress LLC Ibiglustat (succinate) | 1629063-80-4 | 99.7% | 507.57 | 50 MG
Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. It can be utilized for research related to Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.
- Orally active.
- Brain-penetrant glucosylceramide synthase (GCS) inhibitor.
- Can be used for research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.
Medchemexpress LLC Folic acid disodium | 29704-76-5 | 98.6% | 485.36 | 50 MG
Folic acid disodium, also known as Vitamin B9 disodium or Vitamin M disodium, is an orally active disodium salt form of Folic acid. It functions as a cofactor in single-carbon transfer reactions and provides protective effects against neural tube defects, ischemic events, and certain cancers. Conversely, an overload of folic acid disodium can impair brain development during embryogenesis and promote the growth of precancerous altered cells, and a deficiency can lead to megaloblastic anemia.
- Orally active disodium salt form of folic acid.
- Acts as a cofactor in single-carbon transfer reactions.
- Offers protective effects against neural tube defects, ischemic events, and certain cancers.
- High purity of 98.56%.
- Molecular weight of 485.36.
Medchemexpress LLC Actin Related Protein 2 Antibody (YA2725) | 100 UL
This Actin Related Protein 2 Antibody (YA2725) is a rabbit-host antibody designed for various research applications. It reacts with human, mouse, and rat samples, making it suitable for a broad range of studies.
- Host: Rabbit
- Reactivity: Human, mouse, rat
- Applications: WB (1:500-1:1000), ICC/IF (1:50-1:200)
- Molecular weight: Predicted and observed at 45 kDa
- Concentration: 0.3 mg/mL
- Formulation: Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
- Storage & Stability: Stored at -20°C for 1 year, avoid repeated freeze/thaw cycles
- Shipping: With blue ice